… Reversible protein phosphorylation by diverse kinases serves as an additional posttranslational
mechanism controlling p21′s function, localization, binding partners, stability and …

… nuclear localisation and stability of CDKN1A/p21 [14]. Human interacting proteins of … of
mesenchymal markers, suggesting that CDKN1A/p21 is a negative regulator of EMT, and may …

… Following p53 activation, transcription of p21/CDKN1A is strongly induced as a direct target
… Thus, p27 stabilization will cause hypophosphorylation of p130 and subsequent DREAM …

… regulators of p53 include the DDR kinases ATM, ATR, DNA-PK, CHK1, and CHK2. These
modifications release p53 from the interaction with its negative regulator … , the p21 CDKN1A …

… The p21 CDKN1A protein is an important player in the maintenance of genome stability
through … In the DNA damage response, p21 interacts with specific proteins to integrate cell-cycle …

… of the transcriptional activation and repression of CDKN1A.By … after DNA damage in
the absence of p21 stabilization.… Cdk inhibitors: Positive and negative regulators of g1-phase …

… of p53 and p73, we generated stable HCT116 cell lines with either single loss of … of p53/p73-p21
CIP1 and mitotic defects leading to W-CIN, we re-expressed CDKN1A in cells with p53/…

… p21 and its master regulator p53 behaves reciprocally at the mRNA and protein level (Figure
1A,B). p53 … The first trimester-derived HTR cell line displayed a strong p53 and a lesser p21 …

… p53, p21 WAF/CDKN1A is a major negative regulator of cell cycle progression and we observed
increased in p21 expression by p53. … p53 expression by controlling protein stability, and …

… The CDK inhibitor p21, also known as p21waf1 /cip1 or P21/CDKN1A [1], is a small … of
p53 by enhancing p53 stability. Prolyl-isomerase (Pin1) plays a critical role in regulation of p53 …